عنوان المقالة:Synthesis of Ibuprofen-PEG Prodrug and Study the Hydrolysis at Different Phosphate Buffers
د. لقاء عبدالرضا رحيم الربيعي | dr. Leaqaa A.R.Al-Rubaie | 4952
- نوع النشر
- مجلة علمية
- المؤلفون بالعربي
- leaqaa Abd-Alredha R. Al-Rubaie
- الملخص العربي
- Abstract: The present study is conducted to prepare Ibuprofen as polymeric prodrug to improve its important physiochemical properties, increasing water solubility and decrease its side-effects. The product is characterize by using chemical and spectral methods.Then controlled release of Ibuprofen in from its polymer, in different phosphate buffers ( pH =8.5,7.5 and 1).The result show the percentage release of Ibuprofen was high at basic pH.
- تاريخ النشر
- 15/06/2010
- الناشر
- ((Journal of Basrah Researches ((Sciences
- الكلمات المفتاحية
- prodrug, polymeric prodrug, Ibuprofen, PEG