A differential pulse voltammetric method has been developed and certify for the cefdinir expected in special pharmaceuticals. The polarographic behavior of cefdinir was studied at dropping mercury electrode versus Ag/AgCl. Cefdinir show clear reversible catholic reduction peak at approximately - 0.518 V in Britton Robinson buffer at pH 4 and 7 in 0.06M KNO3 or 0.01M
LiCl, whereas the calculated value of the peak potential Ep using Ilkovic - Heyrovsky equation was -0.504V. The choicest planned reduction mechanism recommended that the azomethine group get reduce via a four electrons process closely required for the reduction. The linear range was recognized between 0.875- 7.000 μg.ml-1. The calculated results show that LOD and LOQ were equals to 0.3271and 1.0904 μg.ml-1 respectively. This method was successfully applied to assay cefdinir in commercial capsules with 0.089 standard deviation and relative standard deviation less than 2.97 %. The proposed method is simple, accurate, fewer time consuming and even applied without prior separation for the color and excipient solution.
تاريخ النشر
17/11/2017
الناشر
Global Journal of Science Frontier Research: B Chemistryو Global Journals Inc. (USA)
سلام عباس حسن | Salam A.H. Al-Ameri | 4746