عنوان المقالة:تحضير ودراسة الفعالية البايولوجيه لمركبات حلقية جديدة مشتقة من الهيدرازايد Synthesis and Study the Biological Activity of New Heterocyclic compounds drived from hydrazided dreviatives
رجاء كاظم باقر | Rajaa Kadhium Baker or Baqir | 9817
- نوع النشر
- مقال علمي
- المؤلفون بالعربي
- جمبد هرمز توما ، رجاء كاظم باقر ،وسن مجيد
- المؤلفون بالإنجليزي
- Wasan M. Abd-AL Hameed1, Jumbad H. Tomma2, Rajaa K. Baker3 1Post graduate, Department of Chemistry, College of Education for Pure Science / Ibn Al-Haith
- الملخص العربي
- تم تحضير مجموعة من المركبات الحلقية غير المتجانسة والمشتقه من مركبات الهيدرازيد وكذلك تم دراسة الفعاليه البايولوجيه لها وذلك بدراسة تاثيرها على مجموعة من البكتريا
- الملخص الانجليزي
- ersity of Baghdad Iraq, 3Ass. Prof. Department of Chemistry, College of Education for Pure Science / Ibn Al- Haitham/ University of Baghdad Iraq Abstract The work involves synthesis of new compounds derived from 2-substituted-3-thio- acetohydrazide- 1,2,4-triazin. The subsituted hydrazine thiocarbothioamide [IV] was obtained via reaction of hydrazide compound [III] with ammonium thiocyanate and HCl. The cyclization of compound [IV] in 4% NaOH led to formation 1,2,4-triazoles [V], which were refluxed with chloro-ethylacetate in ethanol and sodium acetate to give compound [VI]. Condensation of ester-compound [VI] with hydrazine (80%) led to formation new hydrazide compounds [VII]. Ring closure reaction of compound [VII] with 4-aminbenzoic acid in POCl3 give 1,3,4-oxadiazoles [VIII]. Compound [VIII] was reacted with sub. benzaldehyde to form compounds of Schiff bases [IX]a-d. The synthesized compounds were diagnosed via IR, Mass and 1HNMR spectral data. Many of synthesized compounds were examined against activity of antibacterial: gram (+) (Bacillus subtitis, staphylococcus aureus) and gram (-): (E.coli bacteria) and candida tropicalis fungial. To ensure the safety of the synthesis compounds the toxicity was examined
- تاريخ النشر
- 01/12/2020
- الناشر
- Indian Journal of Forensic Medicine & Toxicology,
- رقم المجلد
- 14
- رقم العدد
- 4
- الصفحات
- 7
- الكلمات المفتاحية
- : 1,2,4-triazine, 1,2,4-triazoles, 1,3,4-oxadiazoles, Schiff bases, antibacterial activity.