عنوان المقالة: Ethanol Extract of Cordia myxa L Fruit Increase Expression of Antioxidant Enzymes and Tumor Suppressor PTEN Genes in MCF-7 Breast Cancer Cells
In the current study, the cytotoxicity of an ethanol extract from the fruits of Cordia myxa was studied, in
addition to the effect of the extract on the gene expression of antioxidant enzymes such as superoxide
dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) in human breast adenocarcinoma cells
(MCF7). The study also included the effectiveness of the extract to stimulate tumor phosphatase and tensin
homolog (PTEN) gene expression. The results proved that treating MCF7 cells with C. myxa ethanol extract
led to a significant decrease in cell vitality (up to 70%), and the cells treated with ethanol extract showed
higher expression activity of all antioxidant enzymes with real-time PCR results at a concentration of 455.8 μg
/ mL, in this way, it overpowered the cells exposed to H2O2 (200 µM) and not treated with the plant extract
that showed reductions in the expression of enzymes SOD, GPx and CAT., we demonstrated the activity of
C. myxa extract to increase PTEN expression in MCF7 cells approximately 5 to 6 times compared to cells that
were not treated. Results of our study indicated that C. myxa Fruit is useful as a curative agent in prevention
diseases resulting from oxidative exertion
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