عنوان المقالة:التغيرات النسيجية والفسيولوجية في أنسجة الكلى التي يسببها حمض الإيثانويك في الجرذان البيضاء Histological and physiological changes in kidney tissues induced by ethanoic acid in albino rats.
عيدة مفتاح عبدالكريم الشيلابي وسالمة فرج مجيد وأحمد سعيد احميدة
المؤلفون بالإنجليزي
Eda M. A. Alshailabi, Salma F. Majeed and Ahmed S. H. Ahmeedah
الملخص العربي
لا يوجد
الملخص الانجليزي
Ethanoic acid (EA) is a widely used organic acid with corrosive properties. A small amount of its concentration may
cause serious poisoning with a fatal outcome. This study aimed to investigate the histological and physiological changes
on kidney tissues induced by EA in female albino rats. Thirty female rats were used, they were divided into three
groups, one group serves as control group and the other groups were administered the EA as follows: Treated group (1);
animals received EA (1 ml/ kg/ day) with concentration of 5 % and treated group (2); animals received EA (1 ml/ kg/
day) with concentration of 10 % orally by gavage for fourteen days. The mean values of creatinine observed in treated
animals do not differ significantly from the corresponding values observed in controls. Whereas, the results showed a
significant increase in urea levels in rats that received EA-10% as compared to EA-5 % rats and control rats.
Histological observations in kidney tissues showed degeneration of renal glomerulus with widening of Bowman’s
space, hyalinization of glomerular tuft and tubular basement membrane degeneration in glomerulus, indicating dilated
tubule in EA-5% rats. Moreover, the EA-10% groups showed degenerative lesions in glomerulus with lymphocytic
infiltration cells, severe dilatation and vascular congestion with clogging of RBCs. In conclusion, ethanoic acid
consumption have adverse effects on renal function in rats, hence quantity of ethanoic acid should be discouraged or
reduced in making of meals.
تاريخ النشر
30/03/2021
الناشر
International Journal of Multidisciplinary Sciences and Advanced Technology
ا.د. عيدة مفتاح عبدالكريم الشيلابي | Prof. Dr. Eda M. A. Alshailabi | 6197