عنوان المقالة: Amphotericin B from antifungal to antiviral therapy: promising modern therapeutic branch
فلاح حسن عبيس الخيكاني | Falah Hasan Obayes AL_Khikani | 5319
نوع النشر
مجلة علمية
المؤلفون بالعربي
المؤلفون بالإنجليزي
Falah Hasan Obayes AL-Khikani
الملخص الانجليزي
Abstract Introduction: Amphotericin B (AmB) which belongs to the polyene group has a wide spectrum in vitro and in vivo antimicrobial activity against fungi and parasites, but resistance to AmB is rare despite extensive use. Material and methods: Atotal of 2530 articles were investigated in PubMed (n = 1525), Medline (n = 705), and Google Scholar (n = 300). From 2530 articles, only 61 studies were included in this review. All the short and full articles were searched that were scheduled to be published until April 2020. Results: After its discovery, AmB has been one of the most common fist-line choices in treating systemic fungal infection for over seven decades from its discovery. Recently, some studies have focused on the potential antimicrobial action ofAmB against some enveloped and non-enveloped viruses, such as human immunodefiiency virus, Japanese encephalitis virus, herpes simplex virus, and Rubella virus. Discussion: Among the invading pathogens, viruses constitute the most common ones,Due to the continuous spreading of viral infections with the rise in death numbers, new therapeutics development is urgent, as in general, some lethal viruses have no specifi antiviral drugs or vaccines. So, this review may serve as an impetus for researchers working in the fild of medical microbiology, vaccination, and antiviral drug design by discussing the most recent information about the antiviral action ofAmB, as well as trying to provide a deeper understanding of major properties, mechanisms of action, immune system responses, and antimicrobial effiency ofAmB. Conclusion: Since AmB is expected to alter the structure of the viral envelope, membrane integrity of cells, and internal cellular organelles, besides its other unique properties, such as host immunomodulatory effcts, this review suggested that AmB as an effctive anti-fungi drug may hold the promise of formulating a novel therapeutic option to treat many dangerous viruses, including those for treating which there are no active drugs or vaccines.
تاريخ النشر
24/07/2020
رقم المجلد
رقم العدد
رابط DOI
https://doi.org/10.3897/rrpharmacology.6.53649
رابط الملف
تحميل (0 مرات التحميل)
الكلمات المفتاحية
Amphotericin B, antifungal drug, viral infection, antimicrobial agents, antiviral therapy
رجوع