Indole-3-carbinol (I3C) is a major derivative of glucobrassicin (3-indolylmethyl glucosinolate), a plant product common to vegetables of the class Cruciferae. I3C is both an anti-initiator and a promoter of carcinogenesis depending on the timing and dose of administration. This work aimed to evaluate the protective effect and curative role of indole-3-carbinol against acetylsalicylic acid (ASA) induced effects on rat kidney. Male albino rats were divided into four groups of six animals in each group. They were given different experimental inductions of ASA at a dose of 500 mg/kg/body weight and I3C at a dose of 20 mg/kg/body weight either alone or in combination with each other orally for four weeks. The first group (control group) was administrated distilled water for 4 weeks, the second group was administrated ASA, third group was received I3C and fourth group was administrated ASA+I3C. The results of the present study showed that I3C possessed protective activity as evidenced by the inhibition or reduction of histopathological alteration and showed normal histological structure of the glomeruli and tubules at the cortex. The present work provides a strong evidence of I3C produced a permanent protection from ASA induced kidney damage in animal models .
د. عيدة مفتاح عبدالكريم الشيلابي | Dr. Eda M. A. Alshailabi | 5931