عنوان المقالة:مضادات الفطريات من جذور و جذيمرات شرش الزلوع Antiungal compounds from the rhizome and roots of Ferula hermonis
عبدالهادي محمد عبدالهادي الجعفري | Abdel Hadi M. Al Jafari | 3834
نوع النشر
مقال علمي
المؤلفون بالعربي
عبدالهادي الجعفري. روسر فيلا. بلنكا فريشر. فيلكس تومي. جوزيف كازانوفا. جوان كوستا. سلفادور كانيجرال
المؤلفون بالإنجليزي
Abdel-Hadi Al-Ja’fari, Roser Vila, Blanca Freixa, Felix Tomi, Joseph Casanova, Joan Costa, Salvador Cañigueral
الملخص الانجليزي
The antifungal activity of hexane, dichloromethane, methanol and aqueous extracts from the rhizome and root of Ferula hermonis was assayed in vitro by the agar disk diffusion method against a panel of human opportunistic and pathogenic fungi. Among them, the hexane and dichloromethane extracts showed the highest activity particularly against the dermatophytes Microsporum gypseum and Tricophyton mentagrophytes as well as the yeast Candida lactis-condensi. Activity-guided fractionation of both extracts using an agar overlay bioautographic method led to the isolation of two antifungal compounds which were identified as the daucane aryl esters jaeschkeanadiol p-hydroxybenzoate (ferutinin) and jaeschkeanadiol benzoate (teferidin). Determination of minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) values of both compounds evidenced a stronger antifungal activity for ferutinin than for teferidin. Particularly, T. mentagrophytes was the most sensitive strain with MIC and MFC values ranging from 8 to 256 mg/mL.
تاريخ النشر
23/08/2012
الناشر
PHYTOTHERAPY RESEARCH
رقم المجلد
27
رقم العدد
رابط DOI
10.1002/ptr.4806
الصفحات
911-915
الكلمات المفتاحية
Ferula hermonis; jaeschkeanadiol p-hydroxybenzoate; jaeschkeanadiol benzoate; antifungal activity; dermatophytes.
رجوع