عنوان المقالة:المواد الفعالة في الزيوت الطيارة من جذور و جذيمرات شرش الزلوع Composition and antifungal activity of the essential oil from the rhizome and roots of Ferula hermonis
عبدالهادي محمد عبدالهادي الجعفري | Abdel Hadi M. Al Jafari | 3834
- نوع النشر
- مقال علمي
- المؤلفون بالعربي
- عبد لهادي الجعفري. روسر فيلا. بلنكا فريشر. فيلكس تومي. جوزيف كازانوفا. جوان كوستا. سلفادور كانيجرال
- المؤلفون بالإنجليزي
- Abdel-Hadi Al-Ja’fari a,c, Roser Vila a, Blanca Freixa a, Felix Tomi b, Joseph Casanova b, Joan Costa c, Salvador Cañigueral
- الملخص الانجليزي
- The analysis of the essential oil from rhizome and roots of Ferula hermonis Boiss. (Apiaceae) by GC–FID, GC–MS and 13C NMR allowed the identification of 79 constituents, more than 90% of the oil, the major one being a-pinene (43.3%), followed by a-bisabolol (11.1%) and the unusual acetylenic compound 3,5-nonadiyne (4.4%). The antifungal activity of the essential oil before and after fractionation was assayed against several yeasts and filamentous fungi. Purification of the active fractions afforded 3,5-nonadiyne, a-bisabolol, jaeschkeanadiol angelate, a-bisabolol oxide B and trans-verbenol, as well as two purified fractions, one of them (JB73) with 73% of jaeschkeanadiol benzoate and the other with 50% of spathulenol. Determination of MIC and MFC values of all these products evidenced strong antifungal activities for JB73 and 3,5-nonadiyne. Particularly, against the dermatophyte Tricophyton mentagrophytes, MIC and MFC values were 0.25 lg/ml for JB73, and 8 lg/ml for 3,5-nonadiyne, the former being more active than amphotericin B and nystatin.
- تاريخ النشر
- 24/05/2011
- الناشر
- Phytochemistry
- رقم المجلد
- 72
- رقم العدد
- رابط DOI
- doi:10.1016/j.
- الصفحات
- 1406-1413
- الكلمات المفتاحية
- Ferula hermonis Essential oil a-Pinene 3,5-Nonadiyne Jaeschkeanadiol benzoate Antifungal activity Dermatophytes