عنوان المقالة:البحث في التباين في السلوك الانضغاطي خليط الطبقة الثلاثية من منظور الكسر البلاستيكي والمرن في سياق التركيب الأمثل لمزيج صيدلاني Investigating Variation in Compressional Behavior of a Ternary Mixture from a Plastic, Elastic and Brittle Fracture Perspective in the Context of Optimum Composition of a Pharmaceutical Blend
هبة هاني محمد علي, فيصل الكيلة, عبدالهادي الجعفري. إياد رشيد
المؤلفون بالإنجليزي
Hiba Hani Mohammed Ali , Faisal Al-Akayleh , Abdel Hadi Al Jafari, Iyad Rashid
الملخص الانجليزي
The choice of optimum composition of a mixture of binary and ternary excipients for optimum compressional properties was investigated in this work. Excipients were chosen based on three
types of excipients: plastic, elastic, and brittle fracture. Mixture compositions were selected based on
a one-factor experimental design using the response surface methodology technique. Compressive
properties comprising Heckel and Kawakita parameters, work of compression, and tablet hardness
were measured as the main responses of this design. The one-factor RSM analysis revealed that
there exist specific mass fractions that are associated with optimum responses for binary mixtures.
Furthermore, the RSM analysis of the ‘mixture’ design type for the three components revealed a
region of optimal responses around a specific composition. The foregoing had a mass ratio of 80:15:5
for microcrystalline cellulose: starch: magnesium silicate, respectively. Upon comparison using all
RSM data, ternary mixtures were found to perform better in compression and tableting properties
than binary mixtures. Finally, the finding of an optimal mixture composition has proven effective in
its applicability in the context of the dissolution of model drugs (metronidazole and paracetamol).
عبدالهادي محمد عبدالهادي الجعفري | Abdel Hadi M. Al Jafari | 3834