عنوان المقالة:عامل تشخيصي جديد للمريضات العراقيات العقيمات المصابات بمتلازمة تكيس المبايض اللواتي يعانين من داء السكري المعؤضات للاصابه بتصلب الشرايين Novel Biomarker in Polycystic ovary syndrome (PCOS) infertile females with Diabetes Mellitus prone to atherosclerosis
نورهان خالد شفيق | Noorhan Khaled | 4173
نوع النشر
مجلة علمية
المؤلفون بالعربي
با ن شاكر الجوده ,نورهان خالد شفيق ,رائد عبد الحميد
المؤلفون بالإنجليزي
Ban Mahmood Shaker Aljoda * ; Noorhan K. Shfeeq**; Raed A . Abdulhameed
الملخص العربي
The study aimed to evaluate Glucagon-Like Peptide-1 levels in Polycystic ovary syndrome(PCOS) infertile female with Diabetes Mellitus (DM) and compare the results with control group , also , to find the correlation for GLP-1 with Luteinizing hormone(LH), Follicle stimulating hormone(FSH) and LH/FSH ratio that may be used in prediction atherosclerosis in these patients. The study included nineteen women with age ranged(30-40) years and BMI ranged between (30-35) Kg/m2 . Subjects were divided into two groups: group(1) consist of (45)females as a healthy control and group(2) consist of (45) infertile females with PCOS and DM as complication . Fasting serum glucose was determined by using commercial kits (Biolabo SA-France); LH , FSH , prolactin were determined by ELISA, fasting serum insulin was determined by using ELISA kit(DRG-Germany).Insulin-resistance(IR) calculated by (HOMA-IR) . FSH , LH , LH/FSH ratio and prolactin levels for all studied groups were measured . A highly significant elevation in prolactin, LH and LH/FSH ratio was found when G1 comparing with G2 . While significant reduction seen in FSH levels in G2 comparing to G1 . A high significant elevation in Fasting blood glucose , % HbA1C levels in patients group when comparing to healthy control . Results revealed a highly significant elevation in insulin,HOMA-IR and glucagon, while there are a significant reduction in GLP-1levels. There is significant positive correlation was found in GLP-1 levels with (FSH) in G1 ,while a significant negative correlation was observed in levels of GLP-1 and (FSH) inG2. A significant negative correlation was found in GLP-1 levels and (LH) in G1 ,while a positive correlation was found in GLP-1 levels with (LH) in G2 . Results illustrated significant negative correlation was seen in levels of GLP-1 with LH/FSH ratio in G1,while there are a significant positive correlation in GLP-1 levels with LH/FSH ratio in G2 . The conclusion could be drown from this study that GLP-1 has a correlation with LH , FSH which may be considered as a marker in PCOS patients with DM that prone to atherosclerosis significant
تاريخ النشر
04/09/2016
الناشر
Iraqi National Journal of Chemistry
رقم المجلد
15
رقم العدد
1
الكلمات المفتاحية
GLP-1 , insulin resistance , PCOS
رجوع