عنوان المقالة: Synthesis and HPLC resolution of isomers of novel phosphorus fluorinated 2,4,6-trimethylphenylazo pyridines
د. زينب حسيني | Dr. Zineb Hacini | 10954
- نوع النشر
- مقال علمي
- المؤلفون بالعربي
- المؤلفون بالإنجليزي
- Zineb Hacini 1,* and Lakhdar Sekhri
- الملخص الانجليزي
- New compounds of phosphorus fluorinated 2,4,6‐trimethylphenylazo pyridines (4a‐c) have been synthesized in high yields via adding n‐butyl lithium in hexane to a stirred solution of methyldiphenylphosphine oxide in dry THF at 0 °C, then cooled to around ‐78 °C, treated with azo‐pyridines(2a‐c) and then allowed to warm at room temperature over 2 h. The isomers of (E)‐((5‐chloro‐3,6‐difuoro‐4‐(mesityldiazenyl)pyridin‐2‐yl)methyl)diphenyl phosphine oxide (4b) and (E)‐((3,6‐difuoro‐4‐(mesityldiazenyl)5‐methoxypyridin‐2‐yl)methyl)diphenyl phosphine oxide (4c) can be separated on analytical HPLC: Chiralcel OD‐H column, hexane:2‐ PrOH, (9:1, v:v) mobile phase, flow‐rate, 1.0 mL/min, 25 °C, λ = 254 nm and polarimetric detection, 20 μL injection volume. The resolution of this isomers were 2.12, 1.84, respectively.
- تاريخ النشر
- 30/06/2016
- الناشر
- European Journal of Chemistry
- رقم المجلد
- رقم العدد
- رابط DOI
- DOI: 10.5155/eurjchem.7.2.225‐229.1423
- رابط الملف
- تحميل (148 مرات التحميل)
- الكلمات المفتاحية
- Isomers, Synthesis, HPLC resolution, Chiralcel OD‐H column, Phosphorus fluorinated; X‐Ray single crystal structure