Sabah Alharazy, Norella CT Kong, Marlyn Mohd, Shamsul A Shah, Arbaiyah Ba‘in, Abdul Halim Abdul Gafor
الملخص الانجليزي
Abstract
Objective: This longitudinal study aimed to determine the urine
monocyte chemoattractant protein-1 (uMCP-1) levels in patients
with biopsy-proven lupus nephritis (LN) at various stages of
renal disease activity and to compare them to current standard
markers.
Methods: Patients with LN—active or inactive—had their
uMCP-1 levels and standard disease activity markers measured
at baseline and 2 and 4 months. Urinary parameters, renal
function test, serological markers, and renal SLE disease activity
index-2K (renal SLEDAI-2K) were analyzed to determine their
associations with uMCP-1.
Results: A hundred patients completed the study. At each visit,
uMCP-1 levels (pg/mg creatinine) were significantly higher in
the active group especially with relapses and were significantly
associated with proteinuria and renal SLEDAI-2K. Receiver
operating characteristic (ROC) curves showed that uMCP-1 was
a potential biomarker for LN. Whereas multiple logistic
regression analysis showed that only proteinuria and serum
albumin and not uMCP-1 were independent predictors of LN
activity.
Conclusion: uMCP-1 was increased in active LN. Although
uMCP-1 was not an independent predictor for LN activity, it
could serve as an adjunctive marker when the clinical diagnosis
of LN especially early relapse remains uncertain. Larger and
longer studies are indicated.
د. صباح محمد الحرازي | Sabah Mohamed Alharazy | 3067