Back ground: The painful ulcer to the oral mucosa caused by trauma or diseases, represents
the most chief complain of the patients attended to the dentistry clinic. The present study was
undertaken to perform histologic and histomorphometric analysis of the biological effects of
the topical application of leptin on induced traumatic oral mucosal ulcer healing.
Materials and methods: In current study, forty eight male Albino rats weighing
200.45 - 270.53g, and age between 2-3 months, were subjected to traumatic ulcer with 8 mm
diameter by surgical blade no.15 on the right side of the buccal mucosa. The animals were
divided randomly into two groups; the ulcers of the control group treated daily with 10μl of
sterilized distil water, while the study group ulcers treated daily with 10μl of 1 μg/ml of
recombinant leptin. The rats were sacrificed at 3,7,10 days. The specimen were taken and
prepared for histological examination, and histomorphometrical assessment of blood vessels
account and re-epithelization thickness in the ulcer area for both control and study groups.
Results: The histological and histomrphometrical result using leptin as a topical treatment
showed reduced the inflammatory cells infiltration, accelerated the re-epithelization of wound
surface, and enhanced angiogenesis in the ulcer area, resulting with fast tissue healing.
Conclusion: Using leptin as a topical application in the present study for treatment an
abrasion-induced ulcer, revealed that leptin can reduced the ulcer diameter and accelerated the
healing process in a short time.
تاريخ النشر
22/06/2019
الناشر
Annals of Tropical Medicine & Public Health-Special Issues
م.د. صابرين سامي عبد | Lec. Dr. Sabreen Sami Abed | 2997