عنوان المقالة:Synthesis and biological activity of new derivatives of 6-chloro-5-((4- chlorophenyl) diazenyl) pyrimidine-2, 4-diamine and 4-chloro-6-methoxy- N, N-dimethylpyrimidin-2-amine
6-chloro-5-((4-chlorophenyl) diazenyl) pyrimidine-2, 4-diamine and 4-chloro-6-methoxy-N,N-
dimethylpyrimidin-2-amine has been used as precursors for the synthesis of new pyrimidine derivatives,
employing Suzuki cross-coupling reaction. Thus, treatment of pyrimidine derivative with various arylboronic
acids in the presence of palladium tetraacetate, PhP 3 and Na 2 CO 3 in refluxing n-propanol afforded the target
compounds. The synthesis was supported by spectroanalytical techniques. The synthesized compounds have
been screened for their inhibitory activity against some microbial, the results were showed that among gram
positive isolates only (1/10) isolates of S. aureus and (3/10) isolates of S. saprophyticaus were sensitive for
compound 13, while (1/10) isolates of S. aureus and (1/10) isolates of S.saprophyticaus were sensitive for
compound 4. All isolates of S. pyogenes were resisting to all compounds, among gram negative bacterial
isolates only (2/10) isolates of E. coli and (1/10) isolates of K. pneumoniae were sensitive to compound 4.
Concerning the antifungal effects of compounds 3, 4, 5, 13, 14, 15 the results revealed that, all C. albicans and
C. glabrata isolate were resist these compounds.
أ. د ناظر نجم عبدالله الكطراني | Nadhir Najim Abdullah Jafar | 4585