عنوان المقالة:تحضير , تشخيص ودراسة الفعالية البايولوجية لحلقات خماسية وسباعية غير متجانسة Synthesis, Characterization and Study Biological Activity of Five and Seven Heterocyclic Compounds
تحضير مركبات حلقية غير متجانسة الحلقة خماسية وسباعية وتشخيصها بالطرق الطيفية ودراسة تاثيرها على انواع مختلفة من البكتريا
الملخص الانجليزي
The compound 3-((1-(naphthalene-2-yl) ethylidene) amino)-2-thioxo-imidazolidin–4-one [II] was prepared from the cyclization of 2-(1-(naphthalen-2-yl) ethylidene) hydrazine-1-carbothioamide [I] with ethyl α-chloroacetate in the presence of fused CH3COONa. The new 2-thioxo-imidazlidin-4-one derivatives containing heterocyclic unit, five, and seven-member ring were successfully formed, such as imidazoline-4-one, tetrazole, thiazolidin-4-one, and 1,3-oxazepinerings. The synthesized derivatives were characterized by their FTIR,1H-NMR, mass spectra, and CHN-S. Furthermore, the synthesized compounds have been screened for their antibacterial activity against E.col (G-), Staph. Aureus (G+), and Bacillus cereus(G+), and compared to Ampicillin, Amoxicillin, and Lincomycin as antibiotic standards.
منى سمير سعيد | Muna Sameer Saeed AL-rawi | 8822