عنوان المقالة: Design – Syntheses, Characterization and Evaluation Antimicrobial Activity for Some azobenzen-p, p'-disubstituted with (3, O), (3, N-) substitute, (3, H) -quinazolin-4-one-2yl and 4- substituted quinazolin-2yl moieties
Two of 3, O-substituted quinazoline-4-one namely azobenzen-p, p'-di[3, O-benzyl-4 (3H) quinazolin-4-one-2yl], and
azobenzen-p, p'-di[3, O-acetyl-4 (3H) quinazolin-4-one-2yl], were synthesized from azobenzen-p, p'-di[3-hydroxy-4 (3H) quinazolin-4-
one-2yl]. Two of 3-N-substituted quinazoline-4-one namely azobenzen-p, p'-di[3, N-benzensulphonylamide-4 (3H) quinazolin-4-one-
2yl], and azobenzen-p, p'-di[3, N- (4'-nitrofurfurylidine-2'-yl imino) -4 (3H) quinazolin-4-one-2yl], were synthesis from azobenzen-p, p'-
di[3-amino-4 (3H) quinazolin-4-one-2yl]. azobenzen-p, p'-di[3-hydro-4 (3H) quinazolin-4-one-2yl], was synthesized from azobenzen-p,
p'-di (3, 1-benzoaxzine-4-one-2yl], which was used for synthesis azobenzen-p, p'-di[4-chloro-quinazolin-2yl], while its treatment with ptoluidine
and ethylene diamine give azobenzen-p, p'-di[4-N-toludino-quinazolin-2yl], and azobenzen-p, p'-di[4-N-aminoethylaminequinazolin-
2yl] respectively. All synthesized compounds characterized by FTIR, 1HNMR, 13CNMR and mass spectral analyses. All
synthesized compounds, were examined as antibacterial agents against gm (+ve and –ve) bacteria, and antifungal agents. Results
showed abroad extended excellent to moderate effects as antibacterial and antifungal agents.
تاريخ النشر
15/08/2017
الناشر
International Journal of Science and Research (IJSR)
زينب عبدالرزاق جبارة | Zainab Abdul Razzaq Jabarah | 3247