عنوان المقالة:A highly sensitive electrochemical determination of Isoniazid in pharmaceutical preparation by differential pulse polarography
سلام عباس حسن | Salam A.H. Al-Ameri | 4789
- نوع النشر
- مجلة علمية
- المؤلفون بالعربي
- مجلة علمية
- الملخص العربي
- A simple strategy and highly sensitive electrochemical method was developed and described in Britton _ Robinson buffer for Isoniazid determination by Differential Pulse Polarography (DPP). A dropping mercury electrode (DME) was used to characterize the performance of the sensor. The reduction process on the (DME) gave a rise with one peak over Ep-1.17 v (vs. Ag/AgCl/), within the studied pH range (2 – 9), 3M KNO3 as a supporting electrolyte and 4mm3 mercury drop size at 25°C. A standard calibration plot was conducted in the range between 0.05- 0.40μg.ml-1. The monitored differential Pulse current was directly proportional to the concentration of Isoniazid and it showed a linear response in the studied range (correlation coefficient (r) = 0.9997) and the detection limit was 0.05μg. ml-1. This method effectively applied in commercial Isoniazid pharmaceuticals.
- تاريخ النشر
- 31/10/2016
- الناشر
- International Journal of Chemical Engineering Research
- رابط الملف
- تحميل (206 مرات التحميل)
- الكلمات المفتاحية
- Isoniazid, pharmaceutical preparation, Differential pulse polarography.