تم تطبيق طريقة طيفية لتقدير الباراسيتامول في المستحضرات الصيدلانية
الملخص الانجليزي
This research involved the estimation of the percent of paracetamol drug in some manufactured tablets in Iraqi markets using UV
spectroscopy method by determining the active ingredient in ten different samples of tablets and comparisons with standard
material of paracetamol. The process was conducted using different solvent (water, water – methanol mixture 95:5 v/v, water –
methanol mixture 90:10 v/v, water – ethanol mixture 95:5 v/v and water – ethanol mixture 90:10 v/v). The results of tablets
weighing indicate that there is a significant difference in weight of the tablets with RSD ranged from (0.53 – 4.89). The percentage
recovery for different solvents were found to be ranged between (98.19 – 104.16) and RSD ranged from (0.101 – 0.422). The
methods were linear in the range of 1 – 30 mg/L with an R2 of (0.9994, 0.9989, 0.9990, 0.9997 and 0.9998) for water, methanol and
ethanol respectively with a maximum absorbance at 243 nm. Linearity was determined by the regression analysis. The accuracy of
the method was validated by mean percentage recovery, which was found to be in the acceptable range of 99 ‐101.2%. The results
compare favorably with those of official methods.
احمد مهدي سعيد محمد | Ahmed Mahdi Saeed Mohammed | 8542