عنوان المقالة:التاثير الموضعي لمحلول المينوكسديل على نمو الشعر لدى ذكور الفئران Effect of topical minoxidil solution in promoting hair growth in male mice
الخلاصة
اجريت هذه الدراسة لمعرفة مدى تاثير المينوكسديل الموضعي على نمو الشعر لدى ذكور الفئران , حيث استخدم في الدراسة ثلاثون فارا بيض اللون وقد قسمت عشوائيا الى مجموعتين وقد تم حلاقة الظهر قبل يوم من بدء الدراسة وقد اظهرت النتاءج زيادة معنوية في قطر بصيلات الشعر
الملخص الانجليزي
Abstract
The present study was designed to asses the efficacy of topical minoxidil solution in
promoting hair growth in mouse model . This study aimed at finding the more
efficacious drug for the treatment of androgenetic alopecia since the available regimens
have many limitations. Alopecia or Hair loss is the absence or thinness of the hair .
Androgenetic alopecia is commonly referred as male pattern hair loss or female pattern
hair loss in genetically susceptible men and women . 45 albino-Webster male mice were
included in this study , they were divided randomly into two groups, each one included
15 mice . One day before starting the experiment the dorsal skin of each mouse was
shaved by an electric shaver , then stained by using commercial dye and then the
animals were photographed . group No. 1 was considered as control group . It included
mice which did not get any treatment . Group No. 2 received topical minoxidil solution
5% . At the end of treatment ( 21 day), the animals were photographed to asses the
degree of hair growth , it was carried out by means of special computer program called
Photoshop-visual basic-8 program , this program found the ratio of area showing hair
regrowth to the ratio of area denuded of hair . Histological sections were obtained from
each mouse to asses the effect of drugs on the number and diameter of hair follicles.
أ.م.د.قيصر جودة فضيل | Assist.Prof.Dr.Qayssar J Fadheel | 2526