Yasser M Tabana, Saad S Dahham, Amin M Shah, Abdul Majid
الملخص العربي
Colorectal cancer (CRC) is one of the most aggressive
malignant solid tumors which remain a rampant killer
across the world. Toxic drugs have failed to reduce the
morbidity and mortality rate of CRC patients. In addition,
adoption of cancer-causing behaviors has increased the
globule burden of CRC. The disease is characterized by
extensive angiogenesis and perturbation of a variety of oncogenes
and tumor suppressor genes including, p53, Wnt,
hypoxia, NF-кB, Notch, MAP kinase and TGFβ. Targeting
one or more of these signaling pathways increases the selectivity
of the chemotherapeutic agents as these pathways
are important for cancer cells growth and proliferation.
Analysis the multi-step process of this malignant disease
and understanding the underling signaling pathways will
probably facilitate the efficacy of targeted therapy. Colorectal
neoplasms can be prevented by interfering with the
various steps of oncogenesis, which associated with uncontrolled
epithelial cell replication, continues with the
formation of adenomas and eventually evolves into malignancy.
The knowledge described herein will help to understand
the tumorigenesis signaling pathways of this disease
and also will help to prevent or/and treatment CRC.
سعد صبار دحام | Saad Sabbar Dahham | 7166