عنوان المقالة: Design-Syntheses, Characterization and Biological Activity Studies of Azobenzen-P,Pꞌ-Di(3,1-Benzoxazin-4-One-2yl) and Azobenzen-P,Pꞌ-Di[(3- Substituted-3(4H)Quinazolinone-2yl] Derivatives
Sixteen azobenzene-p,pꞌ-di[3-substituted-4(3H)quinazolinone-2yl] were synthesized from reaction of azobenzenp,
pꞌ-di(3,1-benzoaxzin-4-one-2yl) with amino-moieties nucleophlies, like hydrazinehydrate, hydroxylamine,
p,toluidine, p-aminobenzene sulphonamide, 2-pyrimidine, 5-nitro-2-aminopyridine, ethyleneamine,5-(p-bromo)
phenyl-2-aminothiazol, p,pꞌ-diamino diphenyl sulphone, quinidine hydrochloride, urea, thiourea, 3,5-dimethyl-
2-phenyl-4-aminopyrazolin-3-one, N(5-methyl-3-isoxazolyl)-p-aminobenzen sulphonamide, semicarbazide and
thiosemicarbazide, in a molar ratio (1:2) respectively. azobenzen-p,pꞌ-di(3,1-benzoaxzin-4-one-2yl), was synthesized
by following serial synthetic pathway. Reductive-condensation of p-nitrobenzoic acid in basic media give azobenzenp,
pꞌ-dicarboxylic acid, then treated with thionyl chloride to give azobenzen-p,pꞌ-diacid chloride. It condensed with
anthranilic acid to give azobenzen-p,pꞌ-[(dibenzoic acid-2yl)dicarboxamide], upon treatment with thionyl chloride give
azobenzen-p,pꞌ-di(3,1-benzoaxzin-4-one-2yl). All synthesized compounds characterized by FTIR, 1HNMR, 13CNMR
and mass spectral analyses. All synthesized azobenzen-p,pꞌ-di(3,1-benzoaxzin-4-one-2yl), and sixteen azobenzenep,
pꞌ-di[3-substituted-4(3H)quinazolinone-2yl] compounds, were examined as antibacterial agents against gm(+ve
and –ve) bacteria, and antifungal agents. Results showed abroad extended to moderate effects as antibacterial and
antifungal agents.
زينب عبدالرزاق جبارة | Zainab Abdul Razzaq Jabarah | 2267