A model for ascending unobstructed urinary tract infection was developed in female rats to study the
pathogenesis of urinary tract infection by Proteus mirabilis. Urinary bladders of rats were inoculated by I. V.
cannula with 0.5 ml of brainheart infusion broth containing approximately 3 x 108 living bacteria. Kidney, blood
and urine samples collected at days 2, 4 and weeks 1-8 intervals were studied for renal infection as well as renal
function tests.
The results indicated the variation and persistence of Proteus infection in rat's kidneys during the experiment.
Blood urea nitrogen was significantly increased after 2 days and continued to increase throughout the experiment.
Serum creatinine increased significantly on 3rd week and increased steadily to the end of the experiment. Creatinine
clearance fell markedly at 4th day and continued to fall thereafter
حيدر يوسف احمد المراياتي | Hider yousif Ahmed AL-Murayati | 1064