عنوان المقالة: Effect of Zinc oxide nanoparticles (ZnO-NPs) on weights of some reproductive organs and sperm abnormalities in the tail of epididymis of albino mice
Majida Jumaah Radhi and Genan Adnan Abdul Latef Al-Bairuty
الملخص الانجليزي
Increasing use of zinc oxide nanoparticles (ZnO- NPs) in many products may lead to damage of different organ tissues. Therefore, this study was conducted to identify the effect of ZnO-NPs on testicular, epididymal and some accessory glands weights as well as spermatic abnormalities in the epidydimal tail of male albino mice. Animals were orally administrated by 0.1 ml of 100 and 200 mg/kg ZnO-NPs for 7 and 14 days respectively for each concentration. The control group was orally gavaged with 0.1 ml of distilled water. Statistical analysis of the results showed a significant decrease (P≤0.05) in the average body weights of animals after 7 and 14 days of exposure to each treatment compared to the control and the weight of the same animal before treatment. Losing of body weight was increased by elevation the concentration and the duration of exposure. Whereas, the weight of testes and epididymis (head and tail) showed a significant decrease (P≤0.05) with both concentration and duration of exposure compared to the control, with more decreasing in the weight with high concentration and long duration of exposure. The average weight of seminal vesicle and prostate was significantly increased (P≤0.05) with both concentration and duration of exposure compared to control group. The percentage of sperm abnormalities was significantly (P≤0.05) increased with 100 and 200 mg/kg ZnO-NPs for 7 and 14 days of exposure compared to the control. The high concentration of ZnO-NPs and long duration of exposure resulted in more severe changes in the percentage of sperm abnormalities in the epididymis tail. Thus, we can conclude that increasing concentrations of ZnO-NPs and durations of exposure leads to negative effects on the male reproductive efficiency of albino mice.
تاريخ النشر
10/02/2019
الناشر
Journal of Pharmaceutical Sciences and Research ):
جنان عدنان عبد اللطيف البيروتي | Genan Adnan Abdul-Bairuty | 5374