عنوان المقالة:تحضير وتشخيص بعض مشتقات 1،3-ثايازين الجديدة المشتقة من الكومارين SYNTHESIS AND CHARACTERIZATION OF SOME NOVEL 1,3-THIAZINE DERIVATIVES DERIVED FROM COUMARIN
أ.م.د. عبدالامير مطلك فنجان ، م.م. ايناس سالم مهدي
المؤلفون بالإنجليزي
ABDEL AMIR. M. FENJAN & INAS SALIM MAHDI
الملخص الانجليزي
ABSTRACT:
Coumarins (2H-1-benzopyran-2-ones) are important oxygen containing fused heterocycles used in drugs and
dyes. They are the family of lactones containing benzopyrone skeletal framework that have Susceptibility for isolation
from plant as well as total synthesis in the laboratory. 1,3-Thiazines are six membered heterocyclic rings with N-C-S
linkage which have promising pharmacological activities which have attract the attention of scientists. The present study
was designed to synthesis a new Thiazine derivatives from Chalcones which are derived from Coumarin. Compound(1)
(7-hdroxy-4-methyl coumarin) was fused with actamide to gives 1-acetyl-7-hydroxy-4-methyl quinolin-2(1H)-one (2).The
reaction of (2) with various benzeldehyde in presence of alcoholic NaOH leads to production a new series from Chalcones
(3-6). Refluxing of Chalcones with thiourea in presence of alcoholic KOH gives a new derivatives from 1,3 Thiazine (710).These new derivatives were characterized using various physical techniques like: FT- IR ,1H-NMR ,GC-Mass and
C.H.N.S spectra.
تاريخ النشر
09/01/2015
الناشر
International Journal of Humanities, Arts, Medicine and Sciences (BEST: IJHAMS)
ايناس سالم مهدي | Inas Salim Mahdi | 1126