عنوان المقالة:تحضير وتشخيص بعض مشتقات شف بيز الجديدة المشتقة من 7-هيدروكسي-4-مثيل-كومارين Synthesis and Characterization of Some New Schiff Bases Derived from 7-hydroxy-4-methyl Coumarin
Abdel – Amir M. Fenjan , Inas S. Mahdi , Selvana Adwar Yousif
الملخص الانجليزي
Abstract:
Coumarins induce researchers for further developments in organic synthesis because of their pharmaceutical and biological activities. The current research aimed to synthesize new Schiff bases derived from 7-hydroxy-4-methyl-coumarin containing amide, hydrazine carbothioamide, ethylidene moieties. Compound (1) (7-hydroxy-4-methyl coumarin) was converted into quinolin-2(H)-one derivative (2) by the reaction with acetamide. Reaction of derivative (2) with thiosemicarbazide in ethanol leads to the synthesize of (7hydroxy-4-methyl-2-oxoquinolin-1(2H)-yl)ethylidene)hydrazinecarbothioamide derivative (3).Schiff bases(4-6) are prepared through the reaction of (3) with one of aldehydes or ketone. Newcoumarin derivatives are characterized by their physical properties and various spectral analysis like: FTIR, 1HNMR, GC-Ms spectra and micro elemental analysis (C.H.N.S) technique for some of them.
تاريخ النشر
31/01/2017
الناشر
(International Journal of Science and Research (IJSR
ايناس سالم مهدي | Inas Salim Mahdi | 1126