عنوان المقالة:A. A. El-Ghareeb, A. M. El-Bakry, R. G. Ahmed, Asmaa Gaber, 2016. Effects of Zinc Supplementation in Neonatal Hypothyroidism and Cerebellar Distortion Induced by Maternal Carbimazole. Asian Journal of Applied Sciences 4(04), 1030-1040.
A. A. El-Ghareeb, A. M. El-Bakry, R. G. Ahmed, Asmaa Gaber,
الملخص العربي
The aim of this study is to investigate the protective role of Zn on thyroid function and cerebellum
impairments induced by carbimazole (CMI) in neonats at PND 28. Animals were divided into four groups: group I acts as
control; group II received carbimazole(1.35mg/kg.b.wCMI) only; group III received Zn as zinc sulphate (3mg/kg.b.w) and
group IV received Zn and CMI. The administration of maternal CMI caused significant decrease in serum T4, T3 and
growth hormone (GH) levels and significant increase in serum TSH levels in both dams and their newborns relative to
control group. While in Zinc-hypothyroid group, a reverse pattern was noticed for all previous parameters comparing with
hypothyroid group. Maternal CMI administration caused significant decrease in GSH, SOD, GPX, CAT and t-SH of
cerebellum and increased prooxidant levels including MDA, H2O2 and NO while Zn administration to hypothyroid dams
reversed this effect. CMI administration caused some degeneration and deformation innewborns cerebellum while zinc
supplementation to CMI group enhanced structure, length, number and size of purkinje cells, also increase size of the
granular layer.Our results indicated thatzinc has an improvement role on THs levels and histoarchiture of cerebellumdue
to its antioxidant role.
Keywords--- Carbimazole, zinc, thyroid hormones, antioxidant, prooxidant
Ahmed R. G. | Ahmed R. G. | 2259