Thyroid Hormones (THs) play an essential role in development and hormone deficiency during critical phases in fetal life
may lead to severe and permanent brain damage. Maternal iodine deficiency is considered the most common cause of fetal TH
deficiency, but the problem may also arise in the fetus/neonates. Due to defects in fetal thyroid gland development or hormone
synthesis, clinical symptoms at birth are often mild as a result of compensatory maternal TH supply. A shortage of THs starting at the
early stages of pregnancy results in neurological deficits that cannot be rescued by exogenous TH addition at later stages. Neonates
are more sensitive than adults to the effects of iodine deficiency. Thus, these disturbances may lead to abnormalities in the neuronal
network and may result in mental retardation and other neurological defects, including impaired motor skills and visual processing.
Thus, iodine defenses programmes can avoid adverse neurodevelopmental consequences in mothers and their offspring.
Ahmed R. G. | Ahmed R. G. | 2259