عنوان المقالة:Ahmed, R.G., M. Abdel-Latif, Emad Mahdi, Khalid El-Nesr, 2015. Immune stimulation improves endocrine and neural fetal outcomes in a model of maternofetal thyrotoxicosis. International Immunopharmacology 29, 714–721.
Ahmed, R.G., M. Abdel-Latif, Emad Mahdi, Khalid El-Nesr,
الملخص العربي
The potentiation of the immune system in pregnant rats was performed with Complete Freund's Adjuvant [CFA;
20 μl, subcutaneous at gestation day (GD) 18] in experimentally-induced hyperthyroidismby Levo-thyroxine (LT4;
10 μg/100 g of b.w., intraperitoneal from GD 2 to 17). The potential effects on the fetal neuroendocrine function
were evaluated by observing some histopathological investigations in pregnant rats and measuring some
biochemical parameters in dams and their fetuses at GD 20. In hyperthyroid group, an increase in maternofetal
serum thyroxine (T4), triiodothyronine (T3) and a decrease in thyrotropin (TSH) levels were noticed, while
the concentrations of fetal serum growth hormone (GH) and insulin-like growth factor-1 (IGF1) levels were increased
at tested GD with respect to control and CFA groups. Moreover, the activity of uterine and placental
myeloperoxidase (MPO) was increased (P b 0.001) in CFA and CFA-treated hyperthyroid groups in respect to
control or hyperthyroid groups, respectively. The gestational thyrotoxicosis led to some histopathological lesions
in uterine and placental tissues characterized by severe degeneration in trophoblast spongioblast cell layer with
congestion, mild congested blood vessels in the endometrium and deficient in spiral artery remodeling. Although,
the elevation in fetal serum transforming growth factor-beta (TGFβ) and cerebellar monoamines
[norepineprine (NE), epinephrine (E), dopamine (DA) and 5-hydroxytryptamine (5-HT)] was observed, the reduction
in fetal serum tumor necrosis factor-alpha (TNFα) and adipokines (Leptin and adiponectin) was detected.
Treatment of dams with CFA showed an obviously reversing and protecting effect against hyperthyroid
perturbations. Thus, the maternal CFA can be used in treatment of the fetal neuroendocrine dysfunctions.
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