عنوان المقالة: Urinary Monocyte Chemoattractant Protein and Lupus Nephritis Activity
د. صباح محمد الحرازي | Sabah Mohamed Alharazy | 3075
نوع النشر
مجلة علمية
المؤلفون بالعربي
المؤلفون بالإنجليزي
Sabah Alharazy, Norella CT Kong , Marlyn Mohd , Shamsul A Shah , Arbaiyah Báin and Abdul Halim Abdul Gafor
الملخص الانجليزي
Objective: Monocyte chemoattractant protein-1 (MCP-1) is reported to be associated with lupus nephritis (LN) activity. We therefore investigated urinary MCP-1 (uMCP-1) in patients with biopsy proven LN. Methods: This was a cross-sectional observational study in which uMCP-1 levels and the standard parameters of LN activity were measured in these patients. Results: One hundred patients were recruited: 47 with active and 53 inactive LN. uMCP-1 levels were increased in those with active LN [9,317.5 pg/mg creatinine (5,48.3-40,170)] compared to those with inactive LN [3,682 pg/ mg creatinine (0-23,866)] (p<0.001). uMCP-1 correlated with proteinuria (r=0.39, p=0.001), serum albumin (r=-0.35, p=0.001) and SLEDAI-2K (renal) (r=0.39, p=0.001). Area under receiver operating characteristic (AUROC) curve for uMCP-1 was 0.82 (p=0.001) compared with 0.50 (p=0.95), 0.37 (p=0.50), 0.43 (p=0.26) for anti-ds-DNA Ab, C3 and C4 respectively. AUROC for proteinuria was 0.94 (p<0.001) and for SLEDAI-2K (renal) was 0.96 (p<0.001). Only proteinuria and SLEDAI-2K (renal) were independent predictors of LN activity. Conclusions: uMCP-1 may provide further adjunctive evidence if the clinical diagnosis of LN activity remains uncertain and facilitate improved grading of renal disease activity in this complex disease thus leading to improved treatment and outcome. Serial measurements of uMCP-1 are indicated.
تاريخ النشر
28/01/2014
الناشر
Longdom Group SA, Journal of Clinical and Cellular Immunology
رقم المجلد
5
رقم العدد
1
ISSN/ISBN
2155-9899
رابط DOI
10.4172/2155-9899.1000187
الصفحات
1-15
رابط الملف
تحميل (89 مرات التحميل)
رابط خارجي
https://www.longdom.org/abstract/urinary-monocyte-chemoattractant-protein-and-lupus-nephritis-activity-49214.html
الكلمات المفتاحية
Lupus nephritis (LN); Urinary monocyte chemoattractant protein-1 (uMCP-1); Biomarker; Renal flare
رجوع