Background: Hypertension and type 2 diabetes mellitus (T2DM) are major health problems worldwide, associated with excess morbidity and mortality. Serum adiponectin is a biomarker that is associated with type 2 diabetes and hypertension, higher levels are protective while lower circulating levels are risk factors. Objective: To evaluate the adiponectin and lipid profile levels in normotensive and hypertensive type 2 diabetic patients. Method: A case-control study of 510 participants included three groups: (150 type 2 diabetic patients without hypertension, 210 type 2 diabetic patients with hypertension and 150 healthy control). The patients were randomly selected based on World Health Organization (WHO) guideline. Results: The result revealed significant increased values of adiponectin and high-density lipoprotein (HDL) and decreased serum cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) in control group when compared with diabetic normotensive and hypertensive patients groups (p<0.05). The current study also found that the mean of serum TC, TG, LDL and VLDL were higher and decline in serum adiponectin and high-density lipoprotein in hypertensive type 2 diabetic patients compared with non-hypertensive diabetic, although these were not significant (P > 0.05). Hypertensive type 2 diabetic females and males had no significantly higher serum TC, TG, LDL and VLDL and decline in serum adiponectin and HDL when compared with non-hypertensive diabetic females and males, respectively. Conclusion: This study demonstrated that no significant differences of adiponectin and dyslipidemia in hypertensive type 2 diabetic compared with non-hypertensive type 2 diabetic patients.
د. حامد جدوع عباس | Dr. hamed Jadooa Abbas | 12629