عنوان المقالة:تأثير سم النحل L. Apis mellifera في بعض الصفات الفسلجية والنسجية لذكور الجرذان السليمة والمعاملة ببيروكسيد الهيدروجين Effect of Bee venom Apis mellifera L. in some physiological and histological aspects for healthy male rats and treated by hydrogen peroxide.
This study designed to demonstrate the ability of Bee venom (Apis mellifer L.) venom to restore some hematological , biochemical and histopathological changes in male rats treated with hydrogen peroxide , Also studying the effects of crude bee venom on normal rats, Animals randomely divided to 4 groups(6/ group) , Group (1) as control treated with false stings using a pins head at the same treatment rhythm . Group (2) received 1% hydrogen peroxide in drinking water for (49) days . Group (3) stinged with a viable bee venom according to (155) sting program while group (4) received 1% hydrogen peroxide with stings . the results revealded a significant decrease in hemoglobin concentration and packed cell volume at groups (2,3 and 4) with increase in total white blood cells count at group (3) . These hematological changes were combined by biochemical changes in which there was significant increase in serum glucose , cholesterol , triglycerides levels and aspartate aminotransferase , alkaline phosphatase activities at group (2) . Bee venom at group (4) could not adverse the harmfull effects of hydrogen peroxide except regression of glucose and
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triglyceride levels to normal value as control. No biochemical ulteration histopathological examination demonstrate mild to moderate changes at treated groups in liver and kidneys manifested by congestion , acute cell swelling and focal coagulative necrosis in some individuals . Atherosclerotic changes in aorta and some arteries at groups (2 and 4). Several mild degenerative changes were obsearved in myocardium in some individuals from group (4). From this study we concluded that bee venom administration could not prevent or revers the harmful effects of hydrogen peroxide in rats .
كرم هاشم يحيى الملاح | Karam Hashim Yahya Al-Mallah | 1991