عنوان المقالة: Synthesis, Spectral Characteristics, and Biological Activity of 1,3-Oxazepines and 1,3-Oxazepanes Derived from 6-Nitrobenzothiazol-2-amine
1,3-Oxazepine and 1,3-oxazepane derivatives of 6-nitrobenzothiazol-2-amine were synthesized, and
their spectral and antibacterial properties were studied. The condensation of 6-nitrobenzothiazol-2-amine with
aromatic aldehydes gave the corresponding Schiff bases, whose subsequent intermolecular cyclization with maleic
and succinic anhydrides led to the target 1,3-oxazepine and 1,3-oxazepane derivatives. The compositions and
structures of the synthesized compounds were established by elemental analysis and FTIR and 1H NMR spectroscopy.
2-(4-Hydroxy-3-methoxyphenyl)-3-(6-nitrobenzothiazol-2-yl)-1,3-oxazepane-4,7-dione and 2-(4-isopropylphenyl)-
3-(6-nitrobenzothiazol-2-yl)-1,3-oxazepane-4,7-dione showed the highest antibacterial activity
against the gram-positive bacteria Klebsiella pneumonia and Bacillus subtilis, and the gram-negative bacteria
Staphylococcus aureus provide to be highly sensitive to 2-(4-hydroxy-3-methoxyphenyl)-3-(6-nitrobenzothiazol-
2-yl)-1,3-oxazepane-4,7-dione.
هيثم دلول حنون | Haitham Dalol Hanoon | 6855