Nano-emulsions are isotropic dispersed systems of two immiscible
liquids, normally consisting of an oily system dispersed in an aqueous
system, or an aqueous system dispersed in an oily system. The aim of
this study was to formulate Nano-emulsion that is capable of
penetrating the skin easily depending on its size or its homogeneity.
Nano-emulsion was prepared using co-surfactants, Oleic acid as an
oily phase, (Water) as an aqueous phase, Tween 20 as surfactant. The
formulations were prepared, containing of (Vitamin A, Vitamin E,
Lactic Acid, and Hydroquinone) to help in decreasing the signs and
symptoms of skin dryness as emollient and bleaching agent of the skin.
The formulations were characterized for zeta potential, particle size
analysis. The results showed that the formulated nano-emulsions were
of a uniform particle size of 178.9 ± 0.5 nm and with acceptable polydespersity index (PDI)
value of 0.25 which indicate that the particle size distribution falls within a narrow range. The
UV Spectrophotometric analysis showed red shift more than the plain formula, also scanning
electron microscopy confirmed the spherecity of particles. We conclude that the nano-
emulsion containing Vitamin A, Vitamin E, Lactic Acid, and Hydroquinone may serve as an
emollient agent in many skin diseases e.g. age.
تاريخ النشر
24/10/2015
الناشر
WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
احمد عبداللطيف | Ahmed Abdellatif | 1188