Infectious hepatitis infection is the main cause of severe liver failure through the childhood period. People infected with Hepatitis A virus
represents the primary source of this virus. After a person ingests a contaminated food or drink, the live virus invades the body, although it
might/will take 2–6 weeks after exposure for symptoms to manifest. infectious hepatitis prompts an severe infection that consequences in the
removal of the disease via the host, throughout the infection is the consequence of specific immune reactions under the control of cytokines.
The humoral immune system reaction to infectious hepatitis is characterized by the specific production of IgM immunoglobulin against the
VP1 viral protein and IgG immunoglobulin against the VP1 and VP3 viral proteins .In this study established the serum T-helper (Th)17-
related cytokine during distinct hepatitis A virus (HAV)-induced clinical course in children .The clinical spectrum of disease is variable.