عنوان المقالة: Synthesis, characterization and biological evaluation (antifungal and antibacterial) of new derivatives of indole, benzotriazole and thioacetyl chloride
Darda' Aziz Ibrahim, Sarab Dalaf Khalaf, Naglaa Abd Al-Salam Ahmed, Adil Hussein Dalaf
الملخص الانجليزي
2-amino-5-mercapto-1,3,4-thiadiazole is a 2-amino-5-mercapto-1,3,4-thiadiazole derivative. In ethanol, thiosemicarbazide was cyclized with carbon disulfide and anhydrous sodium carbonate to produce M1. The compound (M1) was used in hydrazone reactions with various aromatic aldehydes (M2-M4). Hydrazones (M2-M4) were then reacted with chloro acetyl chloride to produce 5-(sub. benzylidene) amino acids. ] Compounds of -2-thioacetyl chloride-1,3,4-thiadiazole (M5–M7). Compounds (M5–M7) were reacted with benzotriazole to produce compounds (M8–M10) and (M11–M13) (or Indole). Physical properties and spectroscopic details were used to identify all of the synthesized compounds (FT-IR). At the same time, 1H-NMR Spectroscopy was used to identify some of the prepared compounds. Also, certain active functional groups in these compounds have been identified systematically. All of the synthesized compounds were tested for biological activity against two types of bacteria and two fungi types.
عادل حسين دلف | Adil Hussein Dalaf | 3414