عنوان المقالة:Synthesis of Ibuprofen-PEG Prodrug and Study the Hydrolysis at Different Phosphate Buffers
د. لقاء عبدالرضا رحيم الربيعي | dr. Leaqaa A.R.Al-Rubaie | 4230
نوع النشر
مجلة علمية
المؤلفون بالعربي
leaqaa Abd-Alredha R. Al-Rubaie
الملخص العربي
Abstract: The present study is conducted to prepare Ibuprofen as polymeric prodrug to improve its important physiochemical properties, increasing water solubility and decrease its side-effects. The product is characterize by using chemical and spectral methods.Then controlled release of Ibuprofen in from its polymer, in different phosphate buffers ( pH =8.5,7.5 and 1).The result show the percentage release of Ibuprofen was high at basic pH.
تاريخ النشر
15/06/2010
الناشر
((Journal of Basrah Researches ((Sciences
الكلمات المفتاحية
prodrug, polymeric prodrug, Ibuprofen, PEG
رجوع