عنوان المقالة:دور MMP-3 في مستوى مصل مرضى سرطان القولون و المستقيم و المعدة في المرضى العراقيين The Role of MMP-3 Serum Level in both Colorectal and Gastric Cancer in Iraqi Patients
AHMED RUSHDI ABDULLAH*, SHAIMAA YOUSIF ABDULFATTAH AND SAIFALDIN HASHIM KAMAR
الملخص العربي
قياس MMP-3 في مصل مرضى سرطان القولن والمستقيم و المعدة
الملخص الانجليزي
Background: The gastrointestinal tract cancer (GIT cancers) is a worldwide problem, In Iraq, Colorectal Cancer (CRC) is among the Top Ten Cancers (4th) but Gastric Cancer (GC) is not included. Matrix metalloproteinase-3 belongs to the MMP family and is capable of degrading a wide spectrum of substrates. Increased serum concentrations of certain MMP-3 in different types of cancer have been identified, indicating their utility as biomarkers. MMP-3 known with the role of apoptosis creation, angiogenesis modulation, invasion and metastasis in tumor. Materials and Methods: Thirty eight patients with CRC and GC (CRC=21,GC=17) and 20 healthy individuals as a control group were collected, 5-10ml were collected from them.MMP-3 ELISA test was performed to the serum of both, the patients and the control group. Results: Serum MMP-3 levels of the both GITs cancers (CRC+GC) and separately were significantly higher than the control group (P > 0.05). Also, non correlation or association presented between the serum level of MMP-3 and Dukes as well as TNM staging in both GIT cancers. Conclusion: MMP-3 serum level can be a predictive marker for GITs cancers in both CRC and GC collectively or separately.
احمد رشدي عبد الله | Dr Ahmed Rushdi Abdullah | 2653