The sensitivity of human pathogens to some antibiotics used to treat infections and infections caused by these species in humans was tested. The sensitivity of human pathogens to some antibiotics used to treat infections and infections caused by these species in humans was tested. In this study, some pathogenic bacterial isolates, some Gram-negative and Gram-positive, were used. And that from different pathological samples (urine, wound secretions and ear secretions). Obtained from the laboratory of Tishreen University Hospital at Tishreen University in Lattakia Governorate. The sensitivity of pathogenic bacterial isolates to a number of antibiotics was tested using the disk diffusion method. The sensitivity of bacteria was determined by measuring the diameter of the inhibition halos, and its resistance to antibiotics was determined based on the measurement of the diameter of the inhibition zone. The results showed that S. aureus Sensitive only to (SXT) Trimethoprime-Sulfamethoxazole, (VA) Vancomycin, (CN) Gentamycin, and Streptococcus S. faecalis showed sensitivity only to (VA) Vancomycin, (CRO) Ceftriaxone, (AK) Amikacin, (SXT) (rimethoprime-sulfamethoxazole, As for the common P. vulgaris, it was only sensitive to each of the antibiotics (VA) Vancomycin, (AK) Amikacin and (CX) Cloxacillin. And E. coli was allergic only to Trimethoprime-Sulfamethoxa (SXT), (CN)Gentamycin, (LEV) Levofloxacin (SXT) and Amikacin (AK) And if the blue pus bacillus, all strains of P. aeruginosa showed sensitivity only to each of the antibiotics, namely (AK) Amikacin, (CIP) Ciprofloxacin K. pneumoniae showed sensitivity to (VA) Vancomycin, (AK) Amikacin, (LEV) Levofloxacin, (CXm) Cefuroxime, (CRO) Ceftriaxone
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