عنوان المقالة:تحضير، تشخيص و تقدير الفعالية البايولوجية لمعقدات مختلطة الليكاند من البرولين مع المثبريم Synthesis , Characterization and Antibacterial Activities of Co (II),Ni(II),Cu(II),Zn(II),Cd(II)and Hg(II) Mixed-Ligand Complexes of L-Proline and Trimethoprim antibiotic
The Co(II), Ni(II) ,Cu(II), Zn(II) ,Cd(II) and Hg(II) complexes of mixed of amino acid (L-Proline ) and
Trimethoprim antibiotic were synthesized. The complexes were characterized using solubility, melting point,
conductivity measurement ,. and determination the percentage of the metal in the complexes by
flame(AAS).Magnetic susceptibility, Spectroscopic Method [FT-IR and UV-Vis]. Draw the proposed structure
of the complexes using program , Chem. office 3D(2006). The ligands and there metal complexes were
screened for their antimicrobial activity against four bacteria (gram + ve) and (gram -ve){Escherichia coli,
Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus}.The proposed structure of the complexes using
program , Chem office 3D(2006).The general formula have been given for the prepared mixed ligand complexes
[M(Pro)2(TMP)(H2O)]where L-Proline (abbreviated as (ProH ) = C5H9NO2 And Pro- = C5H8NO2
deprotonated primary ligand, L-proline . Trimethoprim (abbreviated as (TMP ) =C10H11N3O3S .
Keywords: Trimethoprim antibiotic, L-Proline , Spectral and antibacterial activities.
Abstract
The Co(II), Ni(II) ,Cu(II), Zn(II) ,Cd(II) and Hg(II) complexes of mixed of amino acid (L-Proline ) and
Trimethoprim antibiotic were synthesized. The complexes were characterized using solubility, melting point,
conductivity measurement ,. and determination the percentage of the metal in the complexes by
flame(AAS).Magnetic susceptibility, Spectroscopic Method [FT-IR and UV-Vis]. Draw the proposed structure
of the complexes using program , Chem. office 3D(2006). The ligands and there metal complexes were
screened for their antimicrobial activity against four bacteria (gram + ve) and (gram -ve){Escherichia coli,
Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus}.The proposed structure of the complexes using
program , Chem office 3D(2006).The general formula have been given for the prepared mixed ligand complexes
[M(Pro)2(TMP)(H2O)]where L-Proline (abbreviated as (ProH ) = C5H9NO2 And Pro- = C5H8NO2
deprotonated primary ligand, L-proline . Trimethoprim (abbreviated as (TMP ) =C10H11N3O3S .
Keywords: Trimethoprim antibiotic, L-Proline , Spectral and antibacterial activities.
ا.د. لقاء خالد عبد الكريم | lekaa khalid abd al-karem | 21406