عنوان المقالة:تحضير وتشخيص وفعالية بايولوجية لمعقداتفازية لقواعد شفالهيدرازونية غير المتجانسة الحلقية Metal Complexes of Heterocyclic Hydrazone Schiff-Bases: Preparation, Spectral Characterisation and Biological Study
انعام اسماعيل يوسف/ رياض محمود احمد/ حسن احمد حسن/ عيد صالح/ محمد جابر الجبوري
English Authors
Enaam I. Yousif1 • Riyadh M. Ahmed1 • Hasan A. Hasan1 • Aeed S. Al-Fahdawi2 • Mohamad J. Al-Jeboor
Abstract
New isatinic hydrazone Schiff-base ligands,
namely furan-2-carboxylic acid (2-oxo-1,2-dihydro-indol-
3-ylidene)-hydrazide (L1), thiophene-2-carboxylic acid (2-
oxo-1,2-dihydro-indol-3-ylidene)-hydrazide (L2) and
2-(pyridine-2-yl-hydrazono)-1,2-dihydro-indol-3-one) (L3)
are reported. The ligands were prepared by the condensation
of furan-2-carboxylic acid hydrazide (L1), thiophene-
2-carboxylic acid hydrazide (L2), and 2-hydrazino pyridine
(L3) with isatine. Monomeric complexes were prepared
from the reaction of the corresponding metal chloride with
the ligands. The ligands and their nine new complexes of
the general formulae [M(Ln)2]Cl2 [where M = Co(II),
Zn(II) and Cd(II); n = L1, L2 and L3] were characterised
by spectroscopic methods (FTIR, UV–Vis, 1H, 13C NMR),
elemental analysis, metal content, magnetic measurement
and molar conductance. These studies revealed the formation
of six coordinate complexes, in which the geometry
about metal atom is a distorted octahedral. Biological
activity of the ligands and their metal complexes against
Gram-positive bacterial strain Bacillus (G?) and Gramnegative
bacteria Ecoli (G-) are evaluated. The effects of
prepared compounds depend on the type of tested bacteria.
It is clear that the ligands and their metal complexes have a
potential effect on the Gram-positive (G?) and Gramnegative
(G-) strains of the tested bacteria.
رياض محمود احمد | Riyadh Mahmood Ahmed | 12047