Saad Sabbar Dahham, Yasser M. Tabana, Mohamed B. Khadeer Ahamed, Amin M.S. Abdul Majid
Abstract
We have recently reported that β-caryophyllene (BCP) can suppress metastasis of colon cancer, induce
apoptosis, and inhibit a broad spectrum of microorganisms. Here, we report anti-inflammatory effect of BCP in
the carrageenan-induced edema paw model, supported by molecular imaging using fluorescence molecular
tomography (FMT). A significant (p<0.01) reduction in paw volumes, and low intensity of fluorescent signal was
noted in experimental animals when compared with negative control. Noteworthy, the low toxicity of BCP and
its high ability of skin penetration attributed to the strong anti-inflammatory and analgesic properties.
Intriguingly, BCP is a natural component of many volatile plants, spices,foods and major constituent of
Cannabis, which is recognized as natural selective agonist to the CB2 receptor. Collectively, the result of present
study illustrate that the anti-inflammatory properties of BCP could be beneficial for prevention and
management inflammation-related diseases.
سعد صبار دحام | Saad Sabbar Dahham | 8311