Alaa S. Alattabi1 , Abeer Thaher Naji AL-Hasnawi2 , Sawsan M. Jabbar AL-Hasnawi3
Abstract
Background: To avoid Rheumatoid arthritis (RA)progression and disability, disease should be detected as early as
possible, which needs diagnostic biomarkers which can dependably anticipate early RA and its progression,
autoantibodies are one of the most reliable diagnostic markers that can be used. Anti-citrullinated protein/peptide
antibodies (ACPA) are one of serological markers of RA. In addition anti-RA33 antibody (Ab) is another serological marker
in RA but its diagnostic utility still dialectical, as it was present in a patients with small proportion.
Objectives: This research aimed to show the combination of anti-RA33Ab and ACPA diagnostic reliability in RA among
Iraqi patients.
Methods: This is a retrospective case- controlled clinical study with a total of 360 subjects. ACPA and Anti-RA33 were
measured by ELISA kits.
Results: The highest positive predictive values were occur in the ACPA with specificity of 98.8% while the highest
negative predictive value were present in the Anti-RA33Ab with sensitivity of 76.1%.
Conclusion: The current results suggests that anti-RA33Ab has the highest diagnostic sensitivity value, so it could be
regarded as important immunodiagnostic marker, but ACPA is more specific for disease.
سوسن محمد جبار الحسناوي | Sawsan M. Jabbar AL-Hasnawi | 3321