Sawsan Mohammed Jabbar AL-Hasnawi*, Suaad Mohammed Hassan Rasheed**/ Salman Aziz Adoos***
Abstract
Immunological profile of LADA is not so clear, so detection of chemokines is quite
important to determine the extent and direction of immune responses.
Objective: the aim of the study is to clarify the levels of chemokines in diabetes mellitus type 2
patients and LADA patients and show their relation with diabetes complications.
Methodology: level of the chemokines CCL2, CCL3and CCL4 were estimated in 90 subjects (34
known LADA cases, 36 D.M.2 cases & 20 healthy control participants), participating patients
were recruited from Diabetes outpatient clinic in AL-Hussein Teaching Hospital in Karbala from
June, 2013 through January, 2014. A clinical questioner containing personal data, family history,
type of diabetes, hemoglobin A1C( HA1C), body mass index (BMI), diabetes duration&
complications of diabetes was obtained from all patients. Statistical analysis done by using the
statistical package for social sciences (SPSS) software for windows, data of all participants were
entered and analyzed with appropriate statistical tests.
Results: significant high level of CCL2in LADA group compared to DM2, a positive correlation
between CCL2 and duration of diabetes. Also CCL2 levels increased more with obese diabetic
patients. .higher concentrations of CCL3 and CCL4 are associated with more complications in
DM2 group.
Discussion: important role of CCL2 in development of autoimmune process in LADA as it is
associated with increased levels among LADA patients. CCL2, CCL3 and CCL4 levels
increased with patients having complications compared to those without complications.
Conclusion: chemokines are associated with complications of diabetes, in addition to the crucial
role of CCL2 in development of autoimmunity of diabetes mellitus.
سوسن محمد جبار الحسناوي | Sawsan M. Jabbar AL-Hasnawi | 3321