Moshera Samy Sameh Hosam Abd El-Alim, Abd El Gawad Rabia , Amal Amin , Magdy M.H. Ayoub
Abstract
The main objective of this study was to evaluate the most suitable conditions to prepare 5-fluorouracil (5-FU)
loaded chitosan nanoparticles (CSNPs). 5-FU loaded CSNPs were prepared employing the ionic gelation technique
using three different molecular weights of CS with the polyanion sodium tripolyphosphate (STPP) as
cross-linking agent. The preparation was based on the ionic interaction of positively charged CS and negatively
charged STPP. The entrapment efficiency (EE%) of CSNPs was in the range of 3.86–21.82% EE% exhibited a clear
increasewith increasing CS concentration. The averge particles sizewas in the nanosize range and monodisperse
in naturewhereas transmission electronmicroscopemicrographs showed that the prepared nanoparticles have a
spherical shape. Fourier transforminfrared (FTIR), X- ray differaction (XRD) and differential scanning calorimetry
(DSC) confirmed successful incorporation of 5-FU in prepared CSNPs. In vitro release of 5-FUfromselected formulations
exhibited sustained release from the nanoparticles where slower release was observed when highermolecular
weight CS was used. The study of drug release kinetics revealed that the release of 5-FU from CSNPs
followed a diffusion controlled pattern.
Publication Date
8/5/2020
Publisher
International Journal of Biological Macromolecules
د.مشيره سامى عبد العزيز يوسف | Dr.Moshera Samy Abdelaziz Youssef | 4303