عنوان المقالة:تأثير بعض مضادات القرحة والأكسدة على الوقاية من قرحة المعدة المستحدثة والتئامها في الجرذان البيضا ء Effect of Antiulcer and Ulcer Healing Property of Some Antioxidants on Experimentally Induced Gastric Ulcer in Albino Rats
The present work is an attempt to elucidate the anti-ulcer activity of indole-3-carbinol as antioxidant alone or in combination with omeprazole a proton pump inhibitor to diminish the effects of induced gastric ulcer by aspirin.
It also emphasizes on the role of omeprazole and indole-3-carbinol on the extent of healing gastric ulcer.
To attain this goal, a total number of 96 male albino rats were presently investigated. It involved different aspects of study namely physiological, biochemical, histological, histochemical and immunohistochemical changes on stomach tissues.
The present findings were then discussed in view of the relevant literature available in similar fields of study.
This study showed that the use of indole -3 - carbinol as antioxidant with omeprazole in the treatment of gastric ulcers in rats, may help in healing gastric ulcers and improvement of all different parameters.
Thus, suggestions for further studies using indole -3 - carbinol as anticancer and antioxidant agent either administrated directly from vegetables of the Cruciferae family or using this active ingredient indole-3 - carbinol in drug preparation of anti-inflammatory drugs.
Abstract
The present work is an attempt to elucidate the anti-ulcer activity of indole-3-carbinol as antioxidant alone or in combination with omeprazole a proton pump inhibitor to diminish the effects of induced gastric ulcer by aspirin.
It also emphasizes on the role of omeprazole and indole-3-carbinol on the extent of healing gastric ulcer.
To attain this goal, a total number of 96 male albino rats were presently investigated. It involved different aspects of study namely physiological, biochemical, histological, histochemical and immunohistochemical changes on stomach tissues.
The present findings were then discussed in view of the relevant literature available in similar fields of study.
This study showed that the use of indole -3 - carbinol as antioxidant with omeprazole in the treatment of gastric ulcers in rats, may help in healing gastric ulcers and improvement of all different parameters.
Thus, suggestions for further studies using indole -3 - carbinol as anticancer and antioxidant agent either administrated directly from vegetables of the Cruciferae family or using this active ingredient indole-3 - carbinol in drug preparation of anti-inflammatory drugs.
Publication Date
1/13/2013
Publisher
Human anatomy, cytology & histology · ain shams univer - women's colloge · RSS Feed
ا.د. عيدة مفتاح عبدالكريم الشيلابي | Prof. Dr. Eda M. A. Alshailabi | 6565