Background: Pollution by pesticides is the main result of technological development in agriculture; Acetamiprid (AC) is a pesticide of the family of new generation organochlorines, so it is controlled by daily doses for short term, but there is a risk in case of chronicity. Aims: The objective of our study is to study biochemical and behavioral neurotoxicity of AC. Methods: In this study, we measured the biomarkers of mitochondrial oxidative stress (GSH, GPx, CAT, SOD, and GST) and brain neurotransmission. Data analysis was performed using Minitab program, a t-test was used to assess the difference between the two groups. Results: The results obtained after administration of AC at 3.14 mg/kg/day of oral weight for 90 days show that AC caused a neurotoxic effect (disruption of neurotransmitter levels). Acetamiprid has an overall pro-oxidative effect;
Abstract
Background: Pollution by pesticides is the main result of technological development in agriculture; Acetamiprid (AC) is a pesticide of the family of new generation organochlorines, so it is controlled by daily doses for short term, but there is a risk in case of chronicity. Aims: The objective of our study is to study biochemical and behavioral neurotoxicity of AC. Methods: In this study, we measured the biomarkers of mitochondrial oxidative stress (GSH, GPx, CAT, SOD, and GST) and brain neurotransmission. Data analysis was performed using Minitab program, a t-test was used to assess the difference between the two groups. Results: The results obtained after administration of AC at 3.14 mg/kg/day of oral weight for 90 days show that AC caused a neurotoxic effect (disruption of neurotransmitter levels). Acetamiprid has an overall pro-oxidative effect;
د. سليم قاسمي | Dr. Salim Gasmi | 23707