عنوان المقالة:Synthesis, Characterization, Structural, Thermal, POM Studies, Antimicrobial and DNA cleavage Activity of a New Schiff Base-Azo Ligand and its Complexation with Selected Metal Ions Synthesis, Characterization, Structural, Thermal, POM Studies, Antimicrobial and DNA cleavage Activity of a New Schiff Base-Azo Ligand and its Complexation with Selected Metal Ions
L.K. Abdul Karem *, F.H. Ganim and R.K. Rahem Al-Shemary
Abstract
Novel Co(II), Cu(II), Ni(II), Cd(II), Zn(II) complexes of Schiff Base- Azo Ligand namely [1,1'-(((1,1')-((3,3')-(ethane-1,2-diylbis(azaneylylidene))bis(1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazole-4-yl-3-ylidene))bis(diazene-2,1-diyl))bis(4-hydroxy-3,1-phenylene))bis(ethan-1-one)] are prepared from 4-amino antypyrine, 1-(4-hydroxyphenyl)ethan-1-one, and ethylene-1,2-diamine. Techniques: The elemental composition and structural environment of the prepared metal complexes are confirmed by 1H, 13C NMR, FT/IR, and CHN elemental analyzer. The λmax and molecular mass is measured with the support of mass and UV-visible spectrometer. All the compounds were screened for their antibacterial and antifungal activity by MIC method. Further, DNA cleavage activity by Agarose Gel Electrophoresis (AGE) method and antioxidant activity was performed by using 2,2-diphenyl-1-picryl-hydrazyl (DPPH). Results: The molar conductivity and magnetic susceptibility measurements signalized that the prepared complexes are designated with an octahedral arrangement. The DNA cleavage activity of the compounds on Calf-thymus DNA (Cat. No-105850) molecule showed moderate activity. Furthermore, the antimicrobial activity results revealed that the metal complexes were found to be more active than the free ligand. The newly synthesized ligand acts as N4O2 donor hexadentate chelate and coordinated through two atoms of azo nitrogen functions, two azomethine nitrogen and two oxygen atoms to the Cu, Co, Cd, Ni and Zn metal ions and form octahedral geometrical arrangements. All the complexes were found to be non-electrolytic in nature. Further, all the newly prepared compounds showed moderat
Abstract
Novel Co(II), Cu(II), Ni(II), Cd(II), Zn(II) complexes of Schiff Base- Azo Ligand namely [1,1'-(((1,1')-((3,3')-(ethane-1,2-diylbis(azaneylylidene))bis(1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazole-4-yl-3-ylidene))bis(diazene-2,1-diyl))bis(4-hydroxy-3,1-phenylene))bis(ethan-1-one)] are prepared from 4-amino antypyrine, 1-(4-hydroxyphenyl)ethan-1-one, and ethylene-1,2-diamine. Techniques: The elemental composition and structural environment of the prepared metal complexes are confirmed by 1H, 13C NMR, FT/IR, and CHN elemental analyzer. The λmax and molecular mass is measured with the support of mass and UV-visible spectrometer. All the compounds were screened for their antibacterial and antifungal activity by MIC method. Further, DNA cleavage activity by Agarose Gel Electrophoresis (AGE) method and antioxidant activity was performed by using 2,2-diphenyl-1-picryl-hydrazyl (DPPH). Results: The molar conductivity and magnetic susceptibility measurements signalized that the prepared complexes are designated with an octahedral arrangement. The DNA cleavage activity of the compounds on Calf-thymus DNA (Cat. No-105850) molecule showed moderate activity. Furthermore, the antimicrobial activity results revealed that the metal complexes were found to be more active than the free ligand. The newly synthesized ligand acts as N4O2 donor hexadentate chelate and coordinated through two atoms of azo nitrogen functions, two azomethine nitrogen and two oxygen atoms to the Cu, Co, Cd, Ni and Zn metal ions and form octahedral geometrical arrangements. All the complexes were found to be non-electrolytic in nature. Further, all the newly prepared compounds showed moderat
ا.د. لقاء خالد عبد الكريم | lekaa khalid abd al-karem | 21771