عنوان المقالة:تحضير و تشخيص و دراسة الفعالية البيولوجية لمعقذات مع الليكانذ متعذد السن الجذيذ Ni(II), Co(II), Mn(II),VO(II) [2-(4-(carboxymethyleneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol3(2H)-ylideneamino)propanoic acid][H2L] type (N2). Synthesis, Characterization and Biological Activity for Complexes VO(II), Mn(II), Co(II) and Ni(II) with new multidentate ligand [2-(4(carboxymethyleneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)ylideneamino)propanoic acid][H2L] type (N2).
In this work, the precursor [(E)-2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4ylimino)acetic acid] was synthesised from 4-aminoantipyrine and glyoxylic acid, this precursor has been used in the synthesis of new multidentate ligand [2-(4-(carboxymethyleneamino)-1,5dimethyl-2-phenyl-1H-pyrazol-3(2H)-ylideneamino)propanoic acid][H2L] type (N2).The ligand was refluxed in ethanol with metal ions [VO(II), Mn(II), Co(II) and Ni(II)] salts to give complexes of general molecular formula:[M(H2L)2(X)(Y)].A, where:M=VO(II),X=0,Y=OSO3-2, A=2H2O; M=Mn(II) ,X=H2O, Y=H2O, A=2Cl; M= Co(II), Ni(II), X=H2O, Y=Cl, A=Cl. These complexes were characterized by atomic absorpition(A.A), F.T-I.R., (U.V-Vis)spectroscopies (1H,13C NMR for ligand only), along with condectivity, elemental microanalysis (C.H.N), chloride content and melting point measurement. These studies revealed an octahedral geometries for VO(II), Mn(II), Co(II) and Ni(II) complexes. The ligand and its complexes exhibited biological activity against the Staphylococcusaureus (G+), E-coli (G-), Pseudomonas (G-) and Proteus (G-) except[Ni(H2L)2(H2O)Cl].Cl with Pseudomonasehas no biological activity.
أ.م.د.ورود علي جعفر | dr.wurood ali jaafar | 11520