عنوان المقالة:المايكروويف ساعدت في تخليق مشتقات امايد من دواء السبروفلوكساسين وفحص الخواص البايولوجية Microwave assisted synthesis of amide derivatives of the drug ciprofloxacin and screening the biological properties
It is synthesis of organic compounds derived from drug ciprofloxacin as amide form
with the help of microwave irradiation. It created a series of these compounds (3a-3n) by ester
derivative as intermediate. These compounds have been diagnosed using the following
spectroscopic methods: IR, 1HNMR and 13CNMR as well as the use of elemental
microanalysis (CHN) found that all spectra match the look and structural molecule. All
compounds proved better effective against bacterial Gram-negative and positive like bacteria
type (Proteus mirabilis, Escherichia coli, Staphylococcus aureus, Granuticetella adiacens).
Keywords: Antibacterial, Thiazole, Ciprofloxcin, DNA gyrase, fluoroquinolones, Amide.
Abstract
It is synthesis of organic compounds derived from drug ciprofloxacin as amide form
with the help of microwave irradiation. It created a series of these compounds (3a-3n) by ester
derivative as intermediate. These compounds have been diagnosed using the following
spectroscopic methods: IR, 1HNMR and 13CNMR as well as the use of elemental
microanalysis (CHN) found that all spectra match the look and structural molecule. All
compounds proved better effective against bacterial Gram-negative and positive like bacteria
type (Proteus mirabilis, Escherichia coli, Staphylococcus aureus, Granuticetella adiacens).
Keywords: Antibacterial, Thiazole, Ciprofloxcin, DNA gyrase, fluoroquinolones, Amide.
نادية صادق مجيد | Nadia Sadiq Majeed | 4714